Groundbreaking Antibiotic Developed by US Scientists Targets Drug-Resistant Superbug<\/p>\n\n\n\n
New York, Jan 4: A team of US scientists has achieved a major breakthrough in combating antibiotic-resistant superbugs with the development of a novel antibiotic called zosurabalpin. Known for its effectiveness against drug-resistant strains of Carbapenem-resistant Acinetobacter baumannii (Crab), which is responsible for severe infections such as sepsis and pneumonia, the antibiotic showed promising results in both laboratory tests and mouse models of infection.<\/p>\n\n\n\n
Two studies published in the journal Nature highlighted the potential of zosurabalpin in treating highly drug-resistant isolates of Crab, addressing a critical need as Crab is categorized as a priority 1 critical pathogen by the World Health Organization. The new antibiotic inhibits the growth of Acinetobacter baumannii by disrupting the movement of lipopolysaccharide (LPS), a large molecule resistant to penetration by many antibiotics, to the outer membrane of the bacteria. This disruption leads to toxic accumulation within the bacterial cell, resulting in cell death.<\/p>\n\n\n\n
Crucially, zosurabalpin exhibited efficacy against over 100 clinical samples of Carbapenem-resistant Acinetobacter baumannii, showcasing its potential as a groundbreaking solution. The antibiotic successfully overcame existing resistance mechanisms in mouse models of pneumonia and sepsis, and is currently undergoing human trials.<\/p>\n\n\n\n
Kenneth Bradley, Global Head of Infectious Disease Discovery at Roche Pharma Research and Early Development, expressed optimism about zosurabalpin, stating, “It represents a promising treatment paradigm for patients with invasive infections due to CRAB, for whom current treatment options are inadequate.”<\/p>\n\n\n\n
Michael Lobritz, Global Head of Infectious Diseases at Roche Pharma Research and Early Development, emphasized the importance of developing antibiotics against high-priority bacteria and highlighted the novel development paths facilitated by regulatory guidelines.<\/p>\n\n\n\n
This development comes as antibiotic resistance poses a significant global health threat, and the research marks a critical step towards addressing the urgent need for effective treatments against drug-resistant pathogens.<\/p>\n","protected":false},"excerpt":{"rendered":"
Groundbreaking Antibiotic Developed by US Scientists Targets Drug-Resistant Superbug New York, Jan 4: A team of US scientists has achieved a major breakthrough in combating antibiotic-resistant superbugs with the development of a novel antibiotic called zosurabalpin. Known for its effectiveness against drug-resistant strains of Carbapenem-resistant Acinetobacter baumannii (Crab), which is responsible for severe infections such […]<\/p>\n","protected":false},"author":1,"featured_media":12974,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[74,14],"tags":[],"class_list":["post-12961","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health","category-international"],"yoast_head":"\n